Mortality rate among Preterm Infants with Respiratory Distress Syndrome on Non-Invasive Respiratory Support (NIRS): A ٌRetrospective multicenter study

Background: Neonatal acute respiratory distress is a common cause for mortality and morbidity in preterm neonates. Non-invasive ventilation crucial neonates, nasal intermittent positive pressure continuous airway pressure. Recently, heated humidified high-flow cannula modes have been revealed as more efficient non-invasive mode improving functional residual capacity however, other studies questioned its efficacy safety comparison to ventilation. Many investigated the predictive factors that are associated with intubation failure of spontaneous breathing. Consequently, this study aimed at investigating prolonged hospital stay death Methodology: prospective multi-center, three-arms, parallel, randomized trial was conducted between four Egyptian NICUs on neonates syndrome delivered entered neonatal intensive care unit using either ventilation, or Mataria Teaching Hospital, Misr Qadema Mabarra Maadi Hospital Gameya Shareya 6th October city. A total 120 from were included study. Informed consents obtained parents each neonate participating full details about procedure benefits. Results: Our has detected lower followed by modes. In fact, median survival time 318 hours which shorter than case (360 hours). Moreover, adjusted odds increased 12% decreased 54% gestational age, weak following 34 weeks, decreases hazard 22%. Furthermore, apnea, pulmonary hemorrhage, bleeding necrosis well hypoventilation predictors failure. Conclusion: Despite known benefits mode, superior preventing both Future large-scale recommended assess factor increasing risk even death.